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Persistent URL http://purl.org/net/epubs/work/54445
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Record Id 54445
Title Self-assembly of peptide nanotubes in an organic solvent
Abstract The self-assembly of a modified fragment of the amyloid peptide, based on sequence A(beta)(16-20), KLVFF, extended to give AAKLVFF is studied in methanol. Self-assembly into peptide nanotubes is observed, as confirmed by electron microscopy and small-angle X-ray scattering. The secondary structure of the peptide is probed by FTIR and circular dichroism, and UV/visible spectroscopy provides evidence for the important role of aromatic interactions between phenylalanine residues in driving (beta)-sheet self-assembly. The (beta)-sheets wrap helically to form the nanotubes, the nanotube wall comprising four wrapped (beta)-sheets. At higher concentration, the peptide nanotubes form a nematic phase that exhibits spontaneous flow alignment as observed by small-angle neutron scattering.
Organisation ISIS , ISIS-LOQ , STFC
Keywords Materials , Chemistry
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Language English (EN)
Type Details URI(s) Local file(s) Year
Journal Article Langmuir 24, no. 15 (2008): 8158-8162. doi:10.1021/la800942n Hamley_Peptide_Nanotube.pdf 2008
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