ePubs

The open archive for STFC research publications

PURL issue currently affecting ePubs. Persistent Uniform Resource Locator (PURL) links in ePubs are not currently working. This is due to a cyber incident that has affected the third-party provider of the PURL system. We are hopeful that this issue will be resolved shortly.

Full Record Details

Persistent URL http://purl.org/net/epubs/work/64619
Record Status Checked
Record Id 64619
Title Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity
Contributors
Abstract Secretory immunoglobulin A (SIgA) is the most prevalent antibody in the human body and a first line of defense in mucosal immunity. We located secretory component (SC) relative to dimeric IgA1 (dIgA1) within the SIgA1 structure using the constrained modeling of solution scattering and analytical ultracentrifugation data. The extended solution structure of dIgA1 is largely preserved within SIgA1. From conformational searches of SC locations, the best-fit SC models within SIgA1 show that SC is extended along the outermost convex edge of the Fc dimer in dIgA1. The topology of our SIgA1 structure reveals that it is able to bind to one FcRI receptor molecule. SC binding to the Fc dimer confers protection to SIgA1 by the masking of proteolytically susceptible surface sites from bacterial proteases in the harsh environment of the mucosa. The models support a "zipper-like" unfolding of SC upon dIgA1 in the formation and transportation of SIgA1 into the mucosa.
Organisation ISIS , ISIS-LOQ , STFC
Keywords
Funding Information
Related Research Object(s):
Licence Information:
Language English (EN)
Type Details URI(s) Local file(s) Year
Journal Article Mucosal Immunology 2, no. 1 (2008): 74-84. doi:10.1038/mi.2008.68 2008